An old woman with Pagets disease

A Grotesque Old Woman (or The Ugly Duchess) is perhaps the best-known of Quentin Matsys' works. It served as a basis for John Tenniel's depiction of the Duchess in Alice's Adventures in Wonderland. It is likely a depiction of a real person with Paget's disease, though it is sometimes said to be a metaphorical portrait of the Duchess Margarete of Tyrol-Görz, who was known as Maultasch, which, though literally translated "satchel mouth", was used to mean "ugly woman" or "whore" (because of her marital scandals).

Painting: A Grotesque Old Woman , Oil on wood, 64 x 45,5 cm, National Gallery, London.