Iproniazid was the first antidepressant ever marketed. It was originally intended for the treatment of tuberculosis.In 1952, its antidepressant properties were discovered when researchers noted that the patients given iproniazid became "inappropriately happy". It was subsequently developed as an antidepressant and was approved for use in 1958.It was later withdrawn in 1961 due to the unacceptable incidence of hepatitis and was replaced by less hepatotoxic drugs like isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).
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