St Barbara and Barbiturates

Barbituric acid was first synthesized on December 6, 1864, by German researcher Adolf von Baeyer. This was done by condensing urea (an animal waste product) with diethyl malonate (an ester derived from the acid of apples). There are several stories about how the substance got its name. The most likely story is that Von Baeyer and his colleagues went to celebrate their discovery in a tavern where the town's artillery garrison were also celebrating the feast of Saint Barbara — the patron saint of artillerists. An artillery officer is said to have christened the new substance by amalgamating Barbara with urea.[1] No substance of medical value was discovered, however, until 1903 when two German chemists working at Bayer, Emil Fischer and Joseph von Mering, discovered that barbital was very effective in putting dogs to sleep. Barbital was then marketed by Bayer under the trade name Veronal. It is said that Von Mering proposed this name because the most peaceful place he knew was the Italian city of Verona.[1] It was not until the 1950s that the behavioural disturbances and physical dependence potential of barbiturates became recognised

Selman Waksman and Streptomycin

Selman Abraham Waksman (22 July 1888 – 16 August 1973) was an American biochemist and microbiologist whose research into organic substances—largely into organisms that live in soil—and their decomposition promoted the discovery of Streptomycin, and several other antibiotics. A professor of biochemistry and microbiology at Rutgers University for four decades, his work led to the discovery of over twenty antibiotics (a word which he coined) and procedures that have led to the development of many others. The proceeds earned from the licensing of his patents funded a foundation for microbiological research, which established the Waksman Institute of Microbiology located on Rutgers University's Busch Campus in Piscataway, New Jersey (USA). In 1952 he was awarded the Nobel Prize in Physiology or Medicine in recognition "for his discovery of "streptomycin" the first antibiotic active against tuberculosis", despite the fact that this medicine was indeed discovered by Albert Schatz, one of Waksman's graduate investigators working under his direction.

In 2005 Selman Waksman was designated an ACS National Historical Chemical Landmark in recognition of his significance for isolating more than fifteen antibiotics, including streptomycin, which was the first effective treatment for tuberculosis

Receiver operating characteristic

In signal detection theory, a receiver operating characteristic (ROC), or simply ROC curve, is a graphical plot of the sensitivity, or true positives, vs. (1 − specificity), or false positives, for a binary classifier system as its discrimination threshold is varied. The ROC can also be represented equivalently by plotting the fraction of true positives (TPR = true positive rate) vs. the fraction of false positives (FPR = false positive rate). Also known as a Relative Operating Characteristic curve, because it is a comparison of two operating characteristics (TPR & FPR) as the criterion changes.

ROC analysis provides tools to select possibly optimal models and to discard suboptimal ones independently from (and prior to specifying) the cost context or the class distribution. ROC analysis is related in a direct and natural way to cost/benefit analysis of diagnostic decision making. The ROC curve was first used during World War II for the analysis of radar signals before it was employed in signal detection theory. Following the attack on Pearl Harbor in 1941, the United States army began new research to increase the prediction of correctly detected Japanese aircraft from their radar signals.

In the 1950s, ROC curves were employed in psychophysics to assess human (and occasionally non-human animal) detection of weak signals. In medicine, ROC analysis has been extensively used in the evaluation of diagnostic tests. ROC curves are also used extensively in epidemiology and medical research and are frequently mentioned in conjunction with evidence-based medicine. In radiology, ROC analysis is a common technique to evaluate new radiology techniques. In the social sciences, ROC analysis is often called the ROC Accuracy Ratio, a common technique for judging the accuracy of default probability models.

ROC curves also proved useful for the evaluation of machine learning techniques. The first application of ROC in machine learning was by Spackman who demonstrated the value of ROC curves in comparing and evaluating different classification algorithms

Razi

Muhammad ibn Zakariyā Rāzī (Mohammad-e Zakariā-ye Rāzi: Persian: محمد زکریای رازی), known as Rhazes or Rasis after medieval Latinists, (August 26, 865, Rayy— 925, Rayy) was a Persian  physician, alchemist and chemist, philosopher, and scholar. He is recognised as a polymathm and Biographies of Razi, based on his writings, describe him as “perhaps the greatest clinician of all times.” Numerous “firsts” in medical research, clinical care, and chemistry are attributed to him, including being the first to differentiate smallpox from measles, and the discovery of numerous compounds and chemicals including alcohol and kerosene, among others. Edward Granville Browne considers him as "probably the greatest and most original of all the physicians, and one of the most prolific as an author".

Although Rhazes (or Razi) was a Persian living in Iran, his work was published in both Persian and Arabic lanugages, as such was the case for most Persian scientists during this era. Such multi-lingual publications in Persia were analogous to the later usage of the Latin language for scientific publications in Europe in the following centuries.

Rhazes made fundamental and enduring contributions to the fields of medicine, alchemy, music, and philosophy, recorded in over 200 books and articles in various fields of science. He was well-versed in Persian, Greek and Indian medical knowledge and made numerous advances in medicine through own observations and discoveries.

Well educated in music, mathematics, philosophy, and metaphysics, he finally chose medicine as his professional field. As a physician, he was an early proponent of experimental medicine and is considered the father of pediatrics. He was also a pioneer of neurosurgery and ophthalmology. He was among the first to use Humoralism to distinguish one contagious disease from another. In particular, Razi was the first physician to distinguish smallpox and measles through his clinical characterization of the two diseases. And as an alchemist, Rhazes is known for his study of sulfuric acid and for his discovery of ethanol and its refinement to use in medicine. He became chief physician of Rayy and Baghdad hospitals. Razi Invented what today is known as rubbing alcohol.

Rhazes was a rationalist and very confident in the power of ratiocination; he was widely regarded by his contemporaries and biographers as liberal and free from any kind of prejudice and very bold and daring in expressing his ideas without a qualm.

He traveled extensively but mostly in Persia. As a teacher in medicine, he attracted students of all disciplines and was said to be compassionate and devoted to the service of his patients, whether rich or poor.